Total synthesis of splenocin B, a potent inhibitor of the pro-inflammatory cytokine from marine-derived Streptomyces sp.

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  • ChemInform Abstract: Total Synthesis of Splenocin B, a Potent Inhibitor of the Pro‐Inflammatory Cytokine from Marine‐Derived Streptomyces sp.

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Description

The first total synthesis of splenocin B (1), a new potent anti-inflammatory antimycin-class antibiotic, has been described. The synthesis of 1 has been accomplished in 8 linear steps, starting from commercially available N-Boc-L-threonine benzyl ester 4 and 3,4-dihydroxypentanoic acid derivative 2. Kita–Trost lactonization via an ethoxyvinyl ester intermediate was utilized for the construction of the 9-membered dilactone core.

Journal

  • Tetrahedron

    Tetrahedron 71 (52), 9626-9629, 2015-12-30

    Elsevier

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