A hippocampal CA3 network model considering the contribution of multiple types of ion channels to frequency boost induced by carbachol

IR IR (HANDLE)

Bibliographic Information

Other Title
  • カルバコールの作用による周波数上昇における複数イオンチャネルの寄与を考慮した海馬CA3神経回路モデル

Search this article

Description

In slice preparations of the rat hippocampal CA3 region, blockade of inhibitory synaptic transmission causes epileptiform oscillations in electric field potentials. However, perfusion with carbachol induces a transition to the theta or beta frequency band (carbachol-induced beta oscillations). To describe the mechanism of carbachol-induced beta oscillations at the ion channel level, we constructed a neural network model of the hippocampal CA3 that accounts for the effects of carbachol. The results suggest that suppression of excitatory synaptic connections, activation of calcium-activated non-selective cationic channels, and inhibition of AHP channels contribute to increased oscillation frequency.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top