Energetics of the single-headed kinesin KIF1A

DOI 機関リポジトリ (HANDLE) HANDLE Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献1件 オープンアクセス

この論文をさがす

説明

KIF1A is a single-headed molecular motor that moves processively and unidirectionally along a microtubule by using the chemical energy released by hydrolyzing adenosine triphosphate (ATP) into adenosine diphosphate (ADP) and inorganic phosphate (Pi). Although the movement of KIF1A seems to have successfully been explained by a simple Brownian motor model of the flashing ratchet type, this model is not suited to discuss the energetics of KIF1A. We introduce an elaborated model of the ratchet type to investigate how the chemical free energy is converted into mechanical work by taking account of the binding and release of reactant (ATP) and product (ADP and Pi) molecules to and from the motor. The efficiency of energy transduction, the power output, and other quantities are calculated from the analytically obtained steady-state solution of the Fokker-Planck equations. It turns out that the concentrations of the reactant and product molecules that optimize both the efficiency and the power are close to those in the cell.

収録刊行物

  • Physical Review E

    Physical Review E 88 (2), 2013-08-14

    American Physical Society (APS)

被引用文献 (1)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ