Evolutionary Origin of OwlRep, a Megasatellite DNA Associated with Adaptation of Owl Monkeys to Nocturnal Lifestyle
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- Nishihara, Hidenori
- Department of Life Science and Technology, Tokyo Institute of Technology
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- Stanyon, Roscoe
- Department of Biology, University of Florence
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- Kusumi, Junko
- Faculty of Social and Cultural Studies, Kyushu University
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- Hirai, Hirohisa
- Primate Research Institute, Kyoto University
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- Koga, Akihiko
- Primate Research Institute, Kyoto University
Description
Rod cells of many nocturnal mammals have a “non-standard” nuclear architecture, which is called the inverted nuclear architecture. Heterochromatin localizes to the central region of the nucleus. This leads to an efficient light transmission to the outer segments of photoreceptors. Rod cells of diurnal mammals have the conventional nuclear architecture. Owl monkeys (genus Aotus) are the only taxon of simian primates that has a nocturnal or cathemeral lifestyle, and this adaptation is widely thought to be secondary. Their rod cells were shown to exhibit an intermediate chromatin distribution: a spherical heterochromatin block was found in the central region of the nucleus although it was less complete than that of typical nocturnal mammals. We recently demonstrated that the primary DNA component of this heterochromatin block was OwlRep, a megasatellite DNA consisting of 187-bp-long repeat units. However, the origin of OwlRep was not known. Here we show that OwlRep was derived from HSAT6, a simple repeat sequence found in the centromere regions of human chromosomes. HSAT6 occurs widely in primates, suggesting that it was already present in the last common ancestor of extant primates. Notably, Strepsirrhini and Tarsiformes apparently carry a single HSAT6 copy, whereas many species of Simiiformes contain multiple copies. Comparison of nucleotide sequences of these copies revealed the entire process of the OwlRep formation. HSAT6, with or without flanking sequences, was segmentally duplicated in New World monkeys. Then, in the owl monkey linage after its divergence from other New World monkeys, a copy of HSAT6 was tandemly amplified, eventually forming a megasatellite DNA.
Journal
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- Genome Biology and Evolution
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Genome Biology and Evolution 10 (1), 157-165, 2018-01
Oxford University Press (OUP)
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Keywords
Details 詳細情報について
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- CRID
- 1050564285810980608
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- NII Article ID
- 120006469173
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- ISSN
- 17596653
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- HANDLE
- 2158/1109890
- 2433/231178
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- PubMed
- 29294004
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
