後肢非荷重による筋萎縮からの回復過程に及ぼすDHEA投与の効果

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  • Effects of DHEA Administration on Recovery from Rat Skeletal Muscle Atrophy Induced by Hind-limb Suspension
  • コウシ ヒカジュウ ニヨル キン イシュク カラ ノ カイフク カテイ ニ オヨボス DHEA トウヨ ノ コウカ

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The purpose of this study was to test the hypothesis that dehydroepiandrosterone (DHEA) accelerate recovery from hind-limb suspension -induced skeletal muscle atrophy in rats by relieving oxidative stress. Male Wistar-strain rats aged 6 weeks were allocated either to the control group or the hind-limb suspended group. Some rats of the suspended group were sacrificed at the end of the suspension of 10 day long. Some other rats of the suspended group were suspended and the allowed to recover for 5 days with DHEA，25mg/kg/day or without DHEA. The rats of the control group were sacrificed at either time points when the suspended rats were sacrificed. For all rats， muscle mass， muscle protein concentration and content were measured. Oxidative stress and anti-oxidative capacity of the serum and skeletal muscles were also evaluated. In the soleus muscle，DHEA did not accelerate the recovery of the muscle mass from the suspension-induced atrophy， although it improved anti-oxidative capacity. In the medial gastrocnemius muscle， DHEA promoted the muscle mass recovery without altering a redox status of the muscle. These results indicate that muscle mass recovery from suspension-induced atrophy does not depend on redox status of the skeletal muscle.

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