書誌事項
- タイトル別名
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- Involvement of endogenous β-endorphin and ε-opioid receptors in supraspinal site on the cold water swimming-induced antinociception in mice
- レイスイ キョウセイ スイエイ ユウハツ コウシンガイ サヨウ ノ ハツゲン ニ オケル ノウナイ ベータ endorphin ナラビニ イプシロン オピオイド ジュヨウタイ ノ カンヨ
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The involvement of endogenous opioid peptides and opioid receptors in supraspinal site on the antinociception induced by cold water swimming was determined using the mouse tail-flick test. The mice forced to swim in cold water for 3 min, showed the marked antinociception. The antinociception induced by cold water swimming was significantly attenuated by intracerebroventricularly (i.c.v.) pretreatment with antiserum against β-endorphin, but not against dynorphin A or [Leu^5] enkephalin. On the other hand, the antinociception was not affected by i.c.v. pretreatment with μ-opioid receptor antagonists β-funaltrexamine and D-Phe-cyclo-(Cys-Tyr-D-Trp-Orn-Thr-Pen)-Thr-NH_2, δ-opioid receptor antagonists naltrindole, 7-benzylidene naltrexone and naltriben, or κ-opioid receptor antagonist nor-binaltorphimine. The present results suggest that the antinociception induced by cold water swimming may be mainly mediated through the release of β-endorphin in the supraspinal site, which act on β-endorphin-sensitive non-μ-, non-δ-, and non-κ-opioid receptor, so called putative ε-opioid receptor.
収録刊行物
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- 東北薬科大学研究誌
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東北薬科大学研究誌 (52), 105-110, 2005-12
仙台 : 東北薬科大学
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詳細情報 詳細情報について
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- CRID
- 1050564287557306880
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- NII論文ID
- 110004814042
- 40015250165
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- NII書誌ID
- AA1149311X
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- ISSN
- 1345157X
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- NDL書誌ID
- 8638086
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- 本文言語コード
- ja
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- 資料種別
- departmental bulletin paper
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- データソース種別
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- IRDB
- NDL
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