Development of the Method for Construction of Benzoxazole Ring via o-Aminophenyl Formate
Bibliographic Information
- Other Title
-
- o-アミノフェノールのギ酸エステル誘導体を用いたベンゾオキサゾール環構築法の開発
- o-アミノフェノール ノ ギサン エステル ユウドウタイ オ モチイタ ベンゾオキサゾールカン コウチクホウ ノ カイハツ
Search this article
Abstract
A novel synthesis of naphtoh[2,1-d]oxazol-5-ol, a model compound for the benzoxazole moiety of marine natural products nakijinols A and B, was achieved in five steps in 35% overall yield starting from commercially available 2-methoxy-1,4-naphthoquinone. The synthesis involved the following crucial steps: ⅰ reduction of an N-Boc-protected 2-amino-1,4-naphthoquione; ⅱ protection of the resulting 2-aminohydronaphthoquinone as its diformate form; ⅲ a simultaneous N-Boc-deprotection and cyclization of the resulting diformate to construct an oxazole ring.
Journal
-
- Journal of Tohoku Pharmaceutical University
-
Journal of Tohoku Pharmaceutical University (61), 27-33, 2014-12
東北薬科大学
- Tweet
Details 詳細情報について
-
- CRID
- 1050564287557364608
-
- NII Article ID
- 110009899353
-
- NII Book ID
- AA1149311X
-
- NDL BIB ID
- 026705387
-
- ISSN
- 1345157X
-
- Text Lang
- ja
-
- Article Type
- departmental bulletin paper
-
- Data Source
-
- IRDB
- NDL
- CiNii Articles