Increased ectopic fat cells in the longitudinal muscularis layer of the oviduct isthmus in obese Japanese Black cows

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  • Increased ectopic fat cells in the longitudinal muscularis layer of the oviduct isthmus in obese <scp>J</scp>apanese <scp>B</scp>lack cows

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<jats:title>Abstract</jats:title><jats:p>In obese humans, mesenchymal stem cells differentiate to become ectopic fat cells in muscles. These ectopic fat cells inhibit the contraction of vascular smooth muscles. Stem cells have been recently identified in the human oviduct, a structure important in reproduction. We therefore investigated the number of <jats:styled-content style="fixed-case">O</jats:styled-content>il <jats:styled-content style="fixed-case">R</jats:styled-content>ed <jats:styled-content style="fixed-case">O</jats:styled-content> (<jats:styled-content style="fixed-case">ORO</jats:styled-content>)‐positive cells in the oviducts of control <jats:styled-content style="fixed-case">J</jats:styled-content>apanese <jats:styled-content style="fixed-case">B</jats:styled-content>lack cows (<jats:italic>n</jats:italic> = 6; body condition score [<jats:styled-content style="fixed-case">BCS</jats:styled-content>], 3.0 on a 5‐point scale) compared to those with diet‐induced obesity (<jats:italic>n</jats:italic> = 5; <jats:styled-content style="fixed-case">BCS</jats:styled-content>, 4.0). We stained the ampulla and isthmus collected on the second day after ovulation with <jats:styled-content style="fixed-case">ORO</jats:styled-content> and then counted the positive cells in each layer in 10 cross‐sections of the ampulla or isthmus. The obese group (23.4 ± 3.4 in the 10 sections) had larger numbers of <jats:styled-content style="fixed-case">ORO</jats:styled-content>‐positive cells in the longitudinal muscularis of the isthmus (<jats:italic><jats:styled-content style="fixed-case">P</jats:styled-content></jats:italic> < 0.05) than did the control group (15.0 ± 2.4). <jats:styled-content style="fixed-case">ORO</jats:styled-content>‐positive cells were also observed in all other layers of the isthmus and ampulla; however, the number of cells in these layers did not differ significantly between obese cows and controls. Whether this observed increase in <jats:styled-content style="fixed-case">ORO</jats:styled-content>‐positive cells in the oviducts of obese cows affects their reproduction warrants further study.</jats:p>

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