Bibliographic Information
- Other Title
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- マクガタ セリンプロテアーゼ MT-SP1 ニ ヨル CDCP1 セツダン オ カイシタ ガン サイボウ ノ アシバ ヒイソン セイノウ ノ カイセキ
- Analysis of the Anchorage-Independence of Cancer Cells through CDCP1 Cleavage by Membrane-Type Serine Protease 1 (MT-SP1)
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Abstract
CUB domain-containing protein 1 (CDCP1) is an important molecule for regulating anchorage-independence involved in cancer metastasis. Recently, it was reported that the synthetic substrate of CDCP1 is cleaved by Membrane-type serine protease 1(MT-SP1), however it is not clear that this cleavage is involved in anchorage-independence. In this study, we investigated the effect of CDCP1 cleavage by MT-SP1 on anchorage-independence in cancer cells by soft agar assay using MT-SP1 siRNA and uncleaved CDCP1 mutant (2RKAAres-F). As a result, cleavage of CDCP1 was inhibited in both experiments, and then the anchorage independence was suppressed. Therefore, it is suggested that the cleavage of CDCP1 by MT-SP1 is involved in the regulation of anchorage independence in cancer cells.
identifier:0385-7301
identifier:http://nda-repository.nda.ac.jp/dspace/handle/11605/139
Journal
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- 防衛大学校 理工学研究報告
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防衛大学校 理工学研究報告 第57巻 (第1号), 11-20, 2019-09
防衛大学校
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Details 詳細情報について
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- CRID
- 1050564288507292288
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- NII Article ID
- 120006728056
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- NII Book ID
- AN00224173
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- ISSN
- 03857301
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- NDL BIB ID
- 030012888
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles