Suppression of Mental Stress-induced Changes by Tandospirone, an Anxiolytic, in Cardiovascular Function
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Description
Effects of anxiolytics on mental stressinduced changes in heart rate and blood pressure were investigated in 54 healthy volunteers, 21-24 years of age, by double blind protocol. The mental stress induced by a computerized color word conflict test increased heart rate and systolic and diastolic blood pressure by 4.2 ± 1.0/min, 5.2 ± 1.9 mmHgand 5.9 ± 1.9 mmHg, respectively. Tandospirone citrate (p.o., 5 mg), a 5HTiA receptor agonist, did not change the resting heart rate or resting blood pressure threeh after administration, whereas metoprolol (p.o.,20 mg), a β1-adrenoceptor antagonist, gradually reduced the resting heart rate and resting systolic blood pressure. Tandospirone significantly inhibited the mental stress-induced increase in heart rate threeh after administration, just as metoprolol did. These findings suggested that a low dose of tandospirone selectively prevents the mental stress-induced changes in cardiovascular activity without affecting the resting state.
Journal
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- Acta medica et biologica
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Acta medica et biologica 54 (4), 103-108, 2006-12
Niigata University School of Medicine
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Details 詳細情報について
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- CRID
- 1050564289185865856
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- NII Article ID
- 110006447061
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- NII Book ID
- AA00508361
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- ISSN
- 05677734
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- HANDLE
- 10191/5235
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- Text Lang
- en
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- CiNii Articles