HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance
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- Nagao, Ayako
- Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University
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- Kobayashi, Minoru
- Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University
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- Koyasu, Sho
- Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University・Research Center for Advanced Science and Technology, The University of Tokyo
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- Chow, Christalle C. T.
- Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University
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- Harada, Hiroshi
- Laboratory of Cancer Cell Biology, Graduate School of Biostudies, Kyoto University
Description
Normal cells produce adenosine 5′-triphosphate (ATP) mainly through mitochondrial oxidative phosphorylation (OXPHOS) when oxygen is available. Most cancer cells, on the other hand, are known to produce energy predominantly through accelerated glycolysis, followed by lactic acid fermentation even under normoxic conditions. This metabolic phenomenon, known as aerobic glycolysis or the Warburg effect, is less efficient compared with OXPHOS, from the viewpoint of the amount of ATP produced from one molecule of glucose. However, it and its accompanying pathway, the pentose phosphate pathway (PPP), have been reported to provide advantages for cancer cells by producing various metabolites essential for proliferation, malignant progression, and chemo/radioresistance. Here, focusing on a master transcriptional regulator of adaptive responses to hypoxia, the hypoxia-inducible factor 1 (HIF-1), we review the accumulated knowledge on the molecular basis and functions of the Warburg effect and its accompanying pathways. In addition, we summarize our own findings revealing that a novel HIF-1-activating factor enhances the antioxidant capacity and resultant radioresistance of cancer cells though reprogramming of the glucose metabolic pathway.
Journal
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- International journal of molecular sciences
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International journal of molecular sciences 20 (2), 238-, 2019-01
MDPI AG
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Keywords
Details 詳細情報について
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- CRID
- 1050564289273972736
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- NII Article ID
- 120006778264
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- ISSN
- 14220067
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- HANDLE
- 2433/245409
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN