Structure-Function Relationship of Immunoglobulin Glycan

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  • 免疫グロブリン結合糖鎖の構造−機能相関
  • 免疫グロブリン結合糖鎖の構造-機能相関
  • メンエキ グロブリン ケツゴウ トウサ ノ コウゾウ-キノウ ソウカン

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Antibodies are glycosylated proteins which play a central role in immune system. much attention has been paid for N-glycosylation at asn297 of igg Fc. it has been well established that the Fc N-glycan is essential for expressingproper effector functions such as Fc receptor binding and complement activation. The underlying mechanism how the N-glycan affect Fc receptor binding has been analyzed and discussed from the structural data. This review will focus on the current understanding how Fc N-glycosylation impacts on the structure and function of the Fc. Finally, techniques are introduced to remodel the N-glycan attached to Fc.

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