Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

Tabata, Sho, Yamamoto, Masatatsu, Goto, Hisatsugu, Hirayama, Akiyoshi, Ohishi, Maki, Kuramoto, Takuya, Mitsuhashi, Atsushi, Ikeda, Ryuji, Haraguchi, Misako, Kawahara, Kohichi, Shinsato, Yoshinari, Minami, Kentaro, Saijo, Atsuro, Hanibuchi, Masaki, Nishioka, Yasuhiko, Sone, Saburo, Esumi, Hiroyasu, Tomita, Masaru, Soga, Tomoyoshi, Furukawa, Tatsuhiko, Akiyama, Shin-ichi

doi:10.1016/j.celrep.2017.04.061

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

DOI 機関リポジトリ Web Site Web Site 被引用文献7件参考文献37件オープンアクセス

説明

Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that TP-mediated thymidine catabolism could supply the carbon source in the glycolytic pathway and thus contribute to cell survival under conditions of nutrient deprivation. In TP-expressing cells, thymidine was converted to metabolites, including glucose 6-phosphate, lactate, 5-phospho-α-D-ribose 1-diphosphate, and serine, via the glycolytic pathway both in vitro and in vivo. These thymidine-derived metabolites were required for the survival of cells under low-glucose conditions. Furthermore, activation of thymidine catabolism was observed in human gastric cancer. These findings demonstrate that thymidine can serve as a glycolytic pathway substrate in human cancer cells.

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

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Thymidine Catabolism as a Metabolic Strategy for Cancer Survival

説明

収録刊行物

被引用文献 (7)*注記

参考文献 (37)*注記

関連プロジェクト

詳細情報 詳細情報について

書き出し

問題の指摘

詳細情報詳細情報について