Thymidine Catabolism as a Metabolic Strategy for Cancer Survival
説明
Thymidine phosphorylase (TP), a rate-limiting enzyme in thymidine catabolism, plays a pivotal role in tumor progression; however, the mechanisms underlying this role are not fully understood. Here, we found that TP-mediated thymidine catabolism could supply the carbon source in the glycolytic pathway and thus contribute to cell survival under conditions of nutrient deprivation. In TP-expressing cells, thymidine was converted to metabolites, including glucose 6-phosphate, lactate, 5-phospho-α-D-ribose 1-diphosphate, and serine, via the glycolytic pathway both in vitro and in vivo. These thymidine-derived metabolites were required for the survival of cells under low-glucose conditions. Furthermore, activation of thymidine catabolism was observed in human gastric cancer. These findings demonstrate that thymidine can serve as a glycolytic pathway substrate in human cancer cells.
収録刊行物
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- Cell Reports
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Cell Reports 19 (7), 1313-1321, 2017-05-16
Elsevier
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詳細情報 詳細情報について
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- CRID
- 1050567903464935040
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- NII論文ID
- 120007001420
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- ISSN
- 22111247
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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