HLA-VBSeq v2: improved HLA calling accuracy with full-length Japanese class-I panel
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抄録
HLA-VBSeq is an HLA calling tool developed to infer the most likely HLA types from high-throughput sequencing data. However, there is still room for improvement in specific genetic groups because of the diversity of HLA alleles in human populations. Here, we present HLA-VBSeq v2, a software application that makes use of a new Japanese HLA reference panel to enhance calling accuracy for Japanese HLA class-I genes. Our analysis showed significant improvements in calling accuracy in all HLA regions, with prediction accuracies achieving over 99.0, 97.8, and 99.8% in HLA-A, B and C, respectively.
収録刊行物
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- Human genome variation
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Human genome variation 6 2019-06-19
Springer Nature
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詳細情報 詳細情報について
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- CRID
- 1050569160001230976
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- NII論文ID
- 120006936353
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- ISSN
- 2054345X
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- HANDLE
- 2433/259357
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- CiNii Articles