- 【Updated on May 12, 2025】 Integration of CiNii Dissertations and CiNii Books into CiNii Research
- Trial version of CiNii Research Knowledge Graph Search feature is available on CiNii Labs
- 【Updated on June 30, 2025】Suspension and deletion of data provided by Nikkei BP
- Regarding the recording of “Research Data” and “Evidence Data”
Bibliographic Information
- Other Title
-
- ニョウロ シンコウ ガン ニ タイスル Mitomycin C Urokina
- Experimental and Clinical Study on Combination Therapy with Mitomycin C and Urokinase for Advanced Urinary Cancers
- 原著
Search this article
Description
type:text
尿路進行癌に対して化学療法を行なうに際し制癌剤の効果を高めるための条件を実験的に検討し,併せて臨床的応用を試みた。実験動物は300g前後の呑龍ラットを用いた。Mitomycin Cを静脈内,腹腔内にone shotで投与した時の血中内MMC濃度の推移を測定,ついでMMC 5mg/kgを静脈内にone shotで投与し,健常の腎,膀胱,睾丸,肝組織のMMC濃度の経時的変化を検討すると,投与後20分で最高組織内濃度に達した。さらに吉田肉腫を膀胱粘膜下,腎,皮下に移植し,MMC単独の場合とPlasminとMMCを併用した場合の腫瘍内濃度を測定した結果,併用したほうが単独の場合よりMMCの腫瘍内濃度が高値を示した。以上を基礎実験としMMC, Urokinase併用療法を尿路進行癌症例に施行し効果のあることを確めた。
In order to carry out the combination therapy of MMC and Urokinase (one of the lysosome labilizers), experiments were carried out using rats and Yoshida ascites sarcoma cells. Combined administration of MMC with Urokinase elevated the MMC concentration in normal tissues and transplanted tumors compared with single administration of MMC. Combination therapy of MMC with Urokinase was carried out for 25 cases with advanced urological cancers. After treatment, reduction of tumors, relief of pain, stop of bleeding, and improvement of other symptoms were observed. In one case., metastatic tumors were disappeared after combination therapy.
Journal
-
- 千葉医学雑誌 = Chiba medical journal
-
千葉医学雑誌 = Chiba medical journal 51 (3), 143-150, 1975-06
千葉医学会
- Tweet
Details 詳細情報について
-
- CRID
- 1050570022174644224
-
- NII Article ID
- 110006442882
-
- NII Book ID
- AN00142148
-
- ISSN
- 03035476
-
- NDL BIB ID
- 1609116
-
- Text Lang
- ja
-
- Article Type
- journal article
-
- Data Source
-
- IRDB
- NDL Search
- CiNii Articles