Comparative study on antibacterial activity of ofloxacin, cefotiam and latamoxef against isolates from clinical specimens in Okinawa

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  • [原著］第2, 3世代セフユム系抗生剤とオフロキサシンの抗菌作用について

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Antibacterial activity of of loxacin as compared with that of cefotiam and latamoxef was determined on 500 isolates from clinical specimens. No bacterial species revealed higher sensitivity to CTM and LMOX than OFLX. In 5 species out of 7 (Staphylococcus aureus, streptococcus faecalis, Escherichia coli, Enterobacter spp., and Pseudomonus, aeruginosa), OFLX was definitely superior to the other 2 cephem drugs. In Serratia marcescens, OFLX and LMOX showed almost the same activity, and CTM was far inferior. In Klebsiella species, all 3 drugs revealed almost the same antimicrobial activity. The most potent bactericidal activity was seen in OFLX. Morphological alteration characterized by elongation of bacteria was observed after the treatment with each drug.

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