Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation
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- 齊藤, 暁
- Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki; Center for Animal Disease Control, University of Miyazaki; Graduate School of Medicine and Veterinary Medicine, University of Miyazaki
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- 入江, 崇
- Institute of Biomedical and Health Sciences, Hiroshima University
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- 鈴木, 理滋
- Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University
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- 前村, 忠
- Division of Virology, Institute of Medical Science, University of Tokyo; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison
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- Nasser, Hesham
- Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University; Department of Clinical Pathology, Faculty of Medicine, Suez Canal University
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- 瓜生, 慧也
- Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
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- 小杉, 優介
- Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
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- 白川, 康太郎
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 貞升, 健志
- Tokyo Metropolitan Institute of Public Health
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- 木村, 出海
- Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
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- 伊東, 潤平
- Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo
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- 呉, 佳齊
- Department of Molecular Life Science, Tokai University School of Medicine; CREST, Japan Science and Technology Agency
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- 岩附, 研子
- Division of Virology, Institute of Medical Science, University of Tokyo
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- 伊藤, 睦美
- Division of Virology, Institute of Medical Science, University of Tokyo
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- 山吉, 誠也
- Division of Virology, Institute of Medical Science, University of Tokyo;The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute
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- Loeber, Samantha
- Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin
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- 津田, 真寿美
- Department of Cancer Pathology, Faculty of Medicine, Hokkaido University; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
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- Wang, Lei
- Department of Cancer Pathology, Faculty of Medicine, Hokkaido University; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
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- 大園, 誠也
- Department of Pathology, National Institute of Infectious Diseases
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- バトラー田中, 英里佳
- Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- 田中, 友理
- Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
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- 清水, 凌
- Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University; Graduate School of Medical Sciences, Kumamoto University
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- 清水, 健太
- Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University
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- 吉松, 組子,
- Institute for Genetic Medicine, Hokkaido University
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- 川端, 涼子
- Institute of Biomedical and Health Sciences, Hiroshima University
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- 坂口, 剛正
- Institute of Biomedical and Health Sciences, Hiroshima University
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- 徳永, 研三
- Department of Pathology, National Institute of Infectious Diseases
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- 吉田, 勲
- Tokyo Metropolitan Institute of Public Health
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- 浅倉, 弘幸
- Tokyo Metropolitan Institute of Public Health
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- 長島, 真美
- Tokyo Metropolitan Institute of Public Health
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- 数馬, 安浩
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 野村, 亮介
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 堀澤, 欣史
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 吉村, 和久
- Tokyo Metropolitan Institute of Public Health
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- 高折, 晃史
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 今井, 正樹
- Division of Virology, Institute of Medical Science, University of Tokyo; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute
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- Chiba, Mika
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Furihata, Hirotake
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Hasebe, Haruyo
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Kitazato, Kazuko
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Kubo, Haruko
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Misawa, Naoko
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Morizako, Nanami
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Noda, Kohei
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Oide, Akiko
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Suganami, Mai
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Takahashi, Miyoko
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Tsushima, Kana
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Yokoyama, Miyabishara
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- Yuan, Yue
- The Genotype to Phenotype Japan (G2P-Japan) Consortium
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- 田中, 伸哉
- Department of Cancer Pathology, Faculty of Medicine, Hokkaido University; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University
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- 中川, 草
- Department of Molecular Life Science, Tokai University School of Medicine; CREST, Japan Science and Technology Agency
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- 池田, 輝政
- Division of Molecular Virology and Genetics, Joint Research Center for Human Retrovirus infection, Kumamoto University
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- 福原, 崇介
- Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University
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- 河岡, 義裕
- Division of Virology, Institute of Medical Science, University of Tokyo; Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison; The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute
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- 佐藤, 佳
- Division of Systems Virology, Department of Infectious Disease Control, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo; CREST, Japan Science and Technology Agency
この論文をさがす
説明
During the current SARS-CoV-2 pandemic, a variety of mutations have accumulated in the viral genome, and currently, four variants of concern (VOCs) are considered potentially hazardous to human society1. The recently emerged B.1.617.2/Delta VOC is closely associated with the COVID-19 surge that occurred in India in the spring of 20212. However, its virological properties remain unclear. Here, we show that the B.1.617.2/Delta variant is highly fusogenic and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters. The P681R mutation in the spike protein, which is highly conserved in this lineage, facilitates spike protein cleavage and enhances viral fusogenicity. Moreover, we demonstrate that the P681R-bearing virus exhibits higher pathogenicity than its parental virus. Our data suggest that the P681R mutation is a hallmark of the virological phenotype of the B.1.617.2/Delta variant and is associated with enhanced pathogenicity.
収録刊行物
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- Nature
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Nature 602 (7896), 300-306, 2022-02-10
Springer Nature
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詳細情報 詳細情報について
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- CRID
- 1050574334845633408
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- ISSN
- 14764687
- 00280836
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- HANDLE
- 2433/275414
- 2115/84468
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- PubMed
- 34823256
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- KAKEN
- OpenAIRE