The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals
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説明
Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.
収録刊行物
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- The Pharmacogenomics Journal
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The Pharmacogenomics Journal 22 247-249, 2022-07-02
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詳細情報 詳細情報について
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- CRID
- 1050574570125253760
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- ISSN
- 1470269X
- 14731150
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- PubMed
- 35780191
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- Web Site
- http://id.nii.ac.jp/1394/00002469/
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- OpenAIRE