De Novo Design of Star-Shaped Glycoligands with Synthetic Polymer Structurestoward an Influenza Hemagglutinin Inhibitor

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説明

Synthetic polymers with well-defined structures allow the development of nanomaterials with additional functions beyond biopolymers. Herein, we demonstrate de novo design of star-shaped glycoligands to interact with hemagglutinin (HA) using well-defined synthetic polymers, with the aim of developing an effective inhibitor for the influenza virus. Prior to the synthesis, the length of the star polymer chains was predicted using the Gaussian model of synthetic polymers, and the degree of polymerization required to achieve multivalent binding to three carbohydrate recognition domains (CRDs) of HA was estimated. The star polymer with the predicted degree of polymerization was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization, and 6’-sialyllactose was conjugated as the glycoepitope for HA. The designed glycoligand exhibited the strongest interaction with HA as a result of the multivalent binding. This finding demonstrated that the biological function of the synthetic polymer could be controlled by precisely defining the polymer structures.

収録刊行物

  • Biomacromolecules

    Biomacromolecules 23 (3), 1232-1241, 2022-03-14

    American Chemical Society

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詳細情報 詳細情報について

  • CRID
    1050580007680237696
  • NII書誌ID
    AA11435474
  • ISSN
    15264602
    15257797
  • HANDLE
    2324/4793641
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB
    • OpenAIRE

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