SYNTHESIS, STEREOCHEMICAL STABILITY, AND BIOLOGICAL ACTIVITY OF STEMONAMINE AND ITS RELATED STEMONA ALKALOIDS

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  • Iwata, Takayuki
    Institute for Materials Chemistry and Engineering, Kyushu University
  • Shindo, Mitsuru
    Institute for Materials Chemistry and Engineering, Kyushu University

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Abstract

More than 140 Stemona alkaloids have been isolated from Stemona plants (of the Stemonaceae species). These alkaloids represent a unique pyrrolo[1,2-a]azepine nucleus, and can be classified into eight groups on the basis of their chemical aspects. This study is focused on the synthesis of stemonamine group alkaloids, in addition to their chemical stability and biological activity.

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