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Self-Assembled Micro-Sized Hexagons Built from Short DNA in a Crowded Environment
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- Self‐Assembled Micro‐Sized Hexagons Built from Short DNA in a Crowded Environment
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Description
DNA programmable structures of various morphologies have attracted extensive attention due to their potential for materials science and biomedical applications. Here, we report the formation of micro-sized hexagons via assembly of only one pair of short double-stranded DNA in buffer-salt poly(ethylene glycol) solution. Each DNA strand had complementary bases with a two-base overhang. The procedure of heating and subsequent cooling of bluntended double-stranded DNA resulted in different assemblies. These results indicated that end-to-end adhesion at the terminals induced by complementary overhangs were required to construct the hexagonal DNA assemblies. The stable formation of the hexagons was highly dependent on heating temperature. In addition, concentration adjustments of DNA and poly(ethylene glycol) were essential. The circular dichroism spectral measurements and polarization microscopy observations indicated a parallel alignment of doublestranded DNA in the hexagonal platelet. Self-assembled micro-sized hexagons composed of simple building blocks may have great potential for future biomedical device development.
Journal
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- ChemBioChem
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ChemBioChem 23 (22), e202200360-, 2022-11-18
Wiley-VCH GmbH
