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Expression and localization of the neuropeptide Y-Y4 receptor in the chick spleen: mRNA upregulation by high ambient temperature
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- Nishimura, Haruka
- Department of Biomedicine, Graduate School of Medical Sciences, Kyushu University
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- Mohamed Z. Elhussiny
- Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University Department of Animal & Poultry Behaviour and Management, Faculty of Veterinary Medicine, Aswan University
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- Ouchi, Yoshimitsu
- Faculty of Veterinary Medicine, Okayama University of Science
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- Haraguchi, Shogo
- Department of Biochemistry, Showa University School of Medicine
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- Itoh, Q. Taichi
- Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University Graduate School of Systems Life Sciences, Kyushu University
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- Elizabeth R. Gilbert
- School of Neuroscience, Virginia Polytechnic Institute and State University
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- Mark A. Cline
- School of Neuroscience, Virginia Polytechnic Institute and State University
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- Nishimura, Shotaro
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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- Hosaka, Z. Yoshinao
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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- Takahashi, Eiki
- Department of Biomedicine, Graduate School of Medical Sciences, Kyushu University
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- John F. Cockrem
- School of Veterinary Science, Massey University
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- Bungo, Takashi
- Faculty of Veterinary Medicine, Okayama University of Science
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- Vishwajit S. Chowdhury
- Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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Description
High ambient temperatures (HT) can increase diencephalic neuropeptide Y (NPY) expression, and central injection of NPY attenuates heat stress responses while inducing an antioxidative state in the chick spleen. However, there is a lack of knowledge about NPY receptor expression, and its regulation by HT, in the chick spleen. In the current study, male chicks were used to measure the expression of NPY receptors in the spleen and other immune organs under acute (30 vs. 40 ± 1°C for 3 h) or chronic (30 vs. 40 ± 1°C for 3 h/day for 3 days) exposure to HT and in response to central injection of NPY (47 pmol, 188 pmol, or 1 nmol). We found that NPY-Y4 receptor mRNA was expressed in the spleen, but not in other immune organs studied. Immunofluorescence staining revealed that NPY-Y4 receptors were localized in the splenic pulp. Furthermore, NPY-Y4 receptor mRNA increased in the chick spleen under both acute and chronic exposure to HT. Central NPY at two dose levels (47 and 188 pmol) and a higher dose (1 nmol) did not increase splenic NPY-Y4 receptor mRNA expression or splenic epinephrine under HT (35 ± 1°C), and significantly increased 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations under HT (40 ± 1°C). In conclusion, increased expression of NPY-Y4 receptor mRNA in the spleen under HT suggest that Y4 receptor may play physiological roles in response to HT in male chicks.
Journal
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- Neuropeptides
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Neuropeptides 107 102459-, 2024-10
Elsevier
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Keywords
Details 詳細情報について
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- CRID
- 1050584088617797888
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- NII Book ID
- AA00324063
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- ISSN
- 15322785
- 01434179
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- HANDLE
- 2324/7326122
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
