Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections

機関リポジトリ (HANDLE) オープンアクセス

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公開日
2025-10-26
資源種別
journal article
権利情報
  • This article is licensed under a Creative Commons Attribution 4.0 International License.
公開者
John Wiley and Sons Inc

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説明

Xiao L., Abe G.L., Sasaki J.I., et al. Gentamicin-Loaded Carbonate Apatite with Dual Antibacterial and Osteogenic Functions for Combating Surgical Site Infections. Advanced Healthcare Materials , (2025); https://doi.org/10.1002/adhm.202503739.

Surgical site infections remain a critical concern in dental and orthopedic procedures. To combat surgical site infections, gentamicin-loaded carbonate apatite (GM-CAp) granules, a novel antibacterial biomimetic bone substitute is developed. GM-CAp granules rapidly release the loaded gentamicin, leading to swift suppression of bacteria and proactive prevention of infection. In vitro studies validate the bactericidal effects of GM-CAp granules against a spectrum of odontogenic bacteria. In vivo investigations confirm the effectiveness of GM-CAp in suppressing Staphylococcus aureus infection, mitigating inflammation, especially neutrophil recruitment, and stimulating bone regeneration. Transcriptomic analysis reveals that early-stage neutrophil dynamics may influence the inflammatory milieu and subsequent bone healing in the infected bone defect following CAp or GM-CAp implantation. Overall, GM-CAp granules represent a potential strategy for combating surgical site infections and increasing the success rate of bone healing in dental and orthopedic surgeries. Additionally, it is proposed that the status of early postoperative neutrophil recruitment may serve as a potential parameter for evaluating the antimicrobial efficacy of biomaterials.

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詳細情報 詳細情報について

  • CRID
    1050588205222633472
  • ISSN
    21922659
    21922640
  • HANDLE
    11094/103460
  • 本文言語コード
    en
  • 資料種別
    journal article
  • データソース種別
    • IRDB

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