Additional Effect of Propiverine for Naftopidil-Resistant Nocturia in the Patient with Benign Prostate Hypertrophy
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- Kamimura, Noritaka
- The Department of Urology, Hirosaki University Graduate School of Medicine
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- Hatakeyama, Shingo
- The Department of Urology, Hirosaki University Graduate School of Medicine
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- Kudo, Shigemasa
- The Department of Urology, Hirosaki University Graduate School of Medicine
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- Yoneyama, Takahiro
- The Department of Urology, Hirosaki University Graduate School of Medicine
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- Hashimoto, Yasuhiro
- Oyokyo Kidney Research Institute Hirosaki Hospital
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- Koie, Takuya
- The Department of Urology, Hirosaki University Graduate School of Medicine
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- Yoshikawa, Kazuaki
- The Department of Urology, Mutsu General Hospital
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- Kawaguchi, Toshiaki
- The Department of Urology, Aomori Prefecture Central Hospital
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- Takahashi, Shinya
- The Department of Urology, Aomori Municipal Hospital
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- Ohyama, Chikara
- The Department of Urology, Hirosaki University Graduate School of Medicine
Bibliographic Information
- Other Title
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- ナフトピジル抵抗性の夜間頻尿を有する前立腺肥大症に対するプロピベリン併用の効果
- ナフトピジル テイコウセイ ノ ヤカンヒンニョウ オ ユウスル ゼンリツセン ヒダイショウ ニ タイスル プロピベリン ヘイヨウ ノ コウカ
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Abstract
The efficacy and safety of additional administration of propiverine were prospectively studied for naftopidil-resistant nocturia in patients with benign prostatic hypertrophy (BPH). Patients of 50 years and over with BPH who experienced nocturia twice a night or more and an overall International Prostate Symptom Score (IPSS) of 8 or more were first administered naftopidil (50 or 75 mg/day) for 4 weeks. Thirty subjects who did not show improvement in nocturia and requested further treatment were enrolled in the present study. Propiverine was then administered concomitantly 10 mg/day for 8 weeks. Significant improvement was observed with additional propiverine in the frequency of nocturia on voiding diary, total IPSS, voiding symptom, storage symptom and nocturnal voiding scores. No significant change was observed in the peak urinary flow rate (Qmax), mean urinary flow rate (Qave), voided urine volume, or residual urine volume. Adverse events were dysuria (2 cases), increased residual urine (6 cases), weak urine flow (1 case), thirsty (2 cases), angular cheilitis (1 case). Administration of propiverine was suspended in 7 subjects, 1 following dysuria and 6 following increased residual urine volume. The suspension of propiverine following increased residual urine volume was significantly more prevalent in subjects with pretreatment Qmax values of less than 10 ml/second or in subjects whose prostate specific antigen (PSA) levels were 2 ng/ml or more. In conclusion, the results indicate that additional administration of propiverine may be useful for the patients with BPH who have naftopidil-resistant nocturia. However, caution must be exercised regarding Qmax and PSA levels.
Journal
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- Hinyokika Kiyo
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Hinyokika Kiyo 57 (2), 71-76, 2011-02
泌尿器科紀要刊行会
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Details 詳細情報について
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- CRID
- 1050845760640017152
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- NII Article ID
- 120002906266
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- NII Book ID
- AN00208315
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- ISSN
- 00181994
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- HANDLE
- 2433/138600
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- NDL BIB ID
- 10985895
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- Text Lang
- ja
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- Article Type
- departmental bulletin paper
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- Data Source
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- IRDB
- NDL
- CiNii Articles