Extracorporeal Partial Nephrectomy and Auto-Transplantation after Presurgical Targeted Therapy with Tyrosine Kinase Inhibitors for Renal Cell Cancer

Nishida, Hayato, Kanno, Hidenori, Hosoya, Noriyuki, Sakurai, Toshihiko, Mashima, Eita, Naito, Sei, Kawazoe, Hisashi, Kato, Tomoyuki, Nagaoka, Akira, Iwaba, Akiko, Yamakawa, Mitsunori, Tomita, Yoshihiko

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腎細胞癌に対して分子標的薬によるPresurgical療法を施行するも継続困難となり，体外腎部分切除および自家腎移植術を施行した1例
ジンサイボウガンニタイシテブンシヒョウテキヤクニヨル Presurgical リョウホウオシコウスルモケイゾクコンナントナリ,タイガイジンブブンセツジョオヨビジカジンイショクジュツオシコウシタ 1レイ

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Abstract

A 74-year-old woman who had previously undergone left nephrectomy because of calculi was referred to our department with a right renal mass that was detected by computed tomography (CT) during treatment for pyelonephritis. Repeated CT showed a contrast-enhanced 4.7 cm tumor close to the renal sinus, and no metastatic lesion was detected. Sunitinib was administered as a presurgical therapy ; however, the patient experienced grade 3 neutropenia and thrombocytopenia, and sunitinib was discontinued. Sorafenib was administered 7 days after discontinuation of sunitinib ; however, the patient experienced febrile neutropenia and rash, and sorafenib was discontinued. Extracorporeal partial nephrectomy and auto-transplantation were performed 24 days after discontinuation of sorafenib. Though peri-graft abscess was suspected to be present and resolved by antibacterial therapy, severe complications were not experienced, and the patient did not require dialysis therapy after surgery. There was no evidence of recurrence at 30 months after the surgery.

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Hinyokika Kiyo

Hinyokika Kiyo 59 (8), 507-511, 2013-08

泌尿器科紀要刊行会

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