Clinical Investigation of Male Infertile Patients with Chromosomal Anomalies

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  • Kuroda, Shinnosuke
    The Department of Urology, Oguchi Higashi General Hospital; Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Yumura, Yasushi
    Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Yasuda, Kengo
    The Department of Urology, Oguchi Higashi General Hospital; Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Yamanaka, Hiroyuki
    Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Takeshima, Teppei
    Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Kobayashi, Masataka
    Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Kato, Yoshitake
    Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Iwasaki, Akira
    Reproduction Medical Center of Urology, Yokohama City University Medical Center
  • Noguchi, Kazumi
    Reproduction Medical Center of Urology, Yokohama City University Medical Center

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Other Title
  • 男性不妊を主訴とした染色体異常患者の検討
  • ダンセイ フニン オ シュソ ト シタ センショクタイ イジョウ カンジャ ノ ケントウ

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Abstract

We investigated 470 male patients who came to the Reproduction Medical Center of Yokohama City University Medical Center complaining of infertility between April 2, 000 and August 2013. We analyzed the chromosomes of 90 patients whose sperm concentration was below 1.0×107/ml. Nineteen of the 90 (21.1%) patients showed sex chromosomal anomalies including 12 Klinefelter syndrome (47, XXY or 46, XY/47, XXY), Robertsonian translocation, 2 autosome-autosome translocation, Y-autosome translocation, 46, X with marker chromosome (46, Xmar＋), XX male and Y chromosome macrodeletion (46, XYq-). While patients with chromosomal abnormalities except XX male or some of 46, XYq- may succeed in reproduction using testicular sperm extraction-intracytoplasmic sperm injection, we need to inform the patients about the risks of chromosomal abnormalities in the resulting fetus.

Journal

  • Hinyokika Kiyo

    Hinyokika Kiyo 60 (7), 309-313, 2014-07

    泌尿器科紀要刊行会

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