The Diversity of Cortical Inhibitory Synapses
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説明
The most typical and well known inhibitory action in the cortical microcircuit is a strong inhibition on the target neuron by axo-somatic synapses. However, it has become clear that synaptic inhibition in the cortex is much more diverse and complicated. Firstly, at least ten or more inhibitory non-pyramidal cell subtypes engage in diverse inhibitory functions to produce the elaborate activity characteristic of the different cortical states. Each distinct non-pyramidal cell subtype has its own independent inhibitory function. Secondly, the inhibitory synapses innervate different neuronal domains, such as axons, spines, dendrites and soma, and their inhibitory postsynaptic potential (IPSP) size is not uniform. Thus, cortical inhibition is highly complex, with a wide variety of anatomical and physiological modes. Moreover, the functional significance of the various inhibitory synapse innervation styles and their unique structural dynamic behaviors differ from those of excitatory synapses. In this review, we summarize our current understanding of the inhibitory mechanisms of the cortical microcircuit.
収録刊行物
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- Frontiers in Neural Circuits
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Frontiers in Neural Circuits 10 1-, 2016-04-25
Frontiers Media SA
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詳細情報 詳細情報について
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- CRID
- 1050845760771244672
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- NII論文ID
- 120005980914
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- ISSN
- 16625110
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- HANDLE
- 2433/218528
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- PubMed
- 27199670
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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