核医学画像と解析の標準化

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  • Standardization of nuclear medicine images and data analysis
  • カク イガク ガゾウ ト カイセキ ノ ヒョウジュンカ

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In nuclear medicine, standardization of quantitative evaluation is important for providing reliable and stable results, and a number of quantitative parameters have been used to evaluate physiology and pathophysiology of organ functions. As a quantitative measure of hot spots in bone scintigraphy, bone scan index (BSI) was introduced and has been increasingly used as a biomarker of the amount of bone metastasis. In nuclear cardiology, standardization among software programs is particularly important, since a number of parameters including myocardial perfusion defect and cardiac function such as ejection fraction, ventricular volumes, and diastolic function are calculated. Recently phase analysis is introduced in various software programs to quantify dyssynchrony of contraction timing, and its characteristics and usefulness have been under investigation. 123I-meta-iodobenzylguanidine (MIBG) sympathetic imaging and parameters have also been standardized and applied to neurology for Lewy-body diseases and to chronic heart failure for prognostication.

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