書誌事項
- タイトル別名
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- ダイ25カイ トクシマ イガッカイショウ ジュショウ ロンブン センタクテキ スプライシング ハンノウ ニ ヨル イデンシ ハツゲン セイギョ
- Regulation of gene expression by alternative splicing
- センタクテキ スプライシング ハンノウ ニヨル イデンシ ハツゲン セイギョ
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抄録
The human genome sequence has been decoded, and the more complicated regulation of gene function is revealed in the post-genome era. In the various mechanisms of epigenome, RNA dramatically controls gene expression through the various post-transcriptional processing including transcription, splicing, cap addition, polyadenylation, nuclear export, translation. Especially, the alternative splicing is involved in all of those post-transcriptional regulations, as well as splicing of pre-mRNA. However, there were few reports, how the alternative splicing contributes to the regulations of cellular functions because of its difficulty of the analysis. This review discusses the molecular mechanism of alternative splicing and its regulator ; Serine/arginine-rich splicing factor (SRSF). We also discuss how the SRSF genes sustain their own proper expressions and functions.
収録刊行物
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- 四国医学雑誌
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四国医学雑誌 66 (5-6), 157-162, 2010-12-20
徳島医学会
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詳細情報 詳細情報について
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- CRID
- 1050845762395233536
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- NII論文ID
- 120006359167
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- NII書誌ID
- AN00102041
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- ISSN
- 00373699
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- NDL書誌ID
- 11000949
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- NDL
- CiNii Articles