DNPIノックアウトマウスの作製

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書誌事項

タイトル別名
  • DNPI ノックアウトマウス ノ サクセイ
  • Generation of DNPI knockout mouse

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説明

A gene-knockout mouse is a mouse in which a particular gene has been artificially destroyed and made dysfunctional. By analyzing symptoms which appear in the gene-knockout mouse's body, we are able to learn the essential function of the knocked-out gene in vivo. Utilizing a gene-knockout mouse, we can ana-lyze the differences between the mouse and a normal mouse of their growth, activity, or abnormalities of their tissues including brains, livers, kidneys and bones. These information from analyzing of a gene-knockout mouse is quite important. For instance, unknown gene functions or connections between genes and diseases can be clarified. Differentiation-associated Na+-dependent inorganic phosphate (Pi) cotransporter (DNPI) is protein that is reported to be associated with transdifferentiation of insulin-secreting cells and regulation of blood glucose levels. We tried to generate DNPI-knockout mouse. The analysis of this mouse clarifies the mech-anism of DNPI and leads to development of future diabetes medical treatment. This review article explained the background of this study and generation of knockout mouse.

identifier:http://repo.kyoto-wu.ac.jp/dspace/handle/11173/1414

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