The influence of age on the sex-related difference in allergic airway inflammation:the effect of progesterone on cytokine production by lymphocytes

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  • アレルギー性気道炎症の性差の加齢変化-サイトカイン産生とプロゲステロンの影響に関する検討-
  • アレルギーセイ キドウ エンショウ ノ セイサ ノ カレイヘンカ サイトカイン サンセイ ト プロゲステロン ノ エイキョウ ニ カンスル ケントウ

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The incidence,severity and prognosis of asthma can be affected by a number of factors,including the patient's age and sex.Clinical observations and epidemiologic studies indicate that the severity of asthma is higher among boys than girls,but that the ratio inverts after puberty.Thereafter,in the elderly,the sex difference disappears.However,the mechanisms underlying the age-related sex differences in the severity of asthma are not clear.Therefore,to clarify the mechanisms we compared using a murine model of asthma allergen-induced airway inflammation and the effect of progesterone on antigen-induced cytokine production by lymphocytes betoween the different age and sex.In 6 weeks old C57BL/6 mice,the airway inflammation in flammation in female mice sensitized with OVA followed by OVA inhalation was more severe than in male mice,whereas the sex difference in the airway inflammation was not observed in 16 weeks old mice.In not only 6 but also 16 weeks old mice,bronchial lymph nodes (BLN) cells from OVA-sensitized female mice produced more Th2 cytokine,than those from age-matched male mice,upon simulation with OVA.Progesterone did not significantly affect the sex difference in Th2 cytokine production by BLN cells in either 6 or 16 weeks old mice.Our findings suggest that the age-related sex differences in allergic airway inflammation are not due to simply the differences in lymphocytes function and sensiticities to progesterone.

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