type:P(論文)

骨粗鬆症予防は最大骨量(PBM)を高め、維持することが重要である。骨量に影響を及ぼす因子として体重、除脂肪体重(LBM)、運動経験や初経などがあり、これらと骨量の関連が多く報告されている。しかし、若年女性を対象にこれらとの関係を検討した研究は少ない。そこで、本研究では女子大学生を対象とし骨量と骨代謝マーカーにより、その変動と要因の関係を検討することを目的とした。同意が得られた本学女子大学生82名(18.7±0.6歳)を対象とし、超音波骨量測定装置(Lunar社、A-1000EXPRESS)にて右踵骨を測定した。併せて身体計測、尿中デオキシピリジノリン(骨吸収マーカー)、過去および現在の運動状況や初経年齢等を調査した。体格と骨量の関係では体重、LBMとBUAの間に正の相関が認められた(p<0.01)。過去および現在の運動継続状況により未経験(n=8)、小学校経験(n=13)、小・中学校継続(n=16)、小・中・高校継続(n=30)、現在まで継続(n=15)の5群に分け検討した結果、骨量は小学校経験群に比べ小・中学校継続群、小・中・高校継続群で高値を示した(p<0.05)。このことから、若年女性の骨量は中学・高校時の定期的運動により影響を受けることが示唆された。また、尿中デオキシピリジノリンは平均8.1±2.0(nmol/mmol・Cr)と基準値を上回っており、初経発来後期間との関係において負の相関(p<0.01)が認められたことから、骨代謝は成熟化に向かっているが完全には安定しておらず、今後の変化を検討する必要があると考えられた。

It's common knowledge that Peak Bone Mass (PBM) is raised more higher level and kept this level for long time to be prevention of Osteoporosis is so important factor. In this longitudinal study, we investigated the relationship of experience of sports in growth period, the bone metabolic marker and ultrasound parameters of the calcaneus in Japanese University student. This study is initial stage (first year). The subjects were 82 women (age 18.7±0.6 years) of the first-year in Wayo University. Calcaneal bone mass was measured by ultrasound bone densitometer (A-1000EXPRESS, Lunar). The speed of sound (SOS), broadband ultrasound attenuation (BUA) and the stiffness index (Stiffness) of the calcaneus in right foot were measured. Urinary deoxypyridinoline (DPD) was measured as a bone absorption markers. Using a questionnaire, the physical activities during elementary school, junior high school, senior high school and the present were researched. At the same time, menarche age and menstrual cycle were researched. In results, the subjects were divided into five groups according to physical activities (PA group): the physically non-active group, the PA group on elementary school, the PA group from elementary to junior high school, the PA group from elementary to senior high school and the PA group from elementary to now. The average of the Stiffness was shown significant differences among five groups (p < 0.05). The group of junior and senior high school actives was higher Stiffness than elementary actives. The DPD was significant higher than standard value. Negative correlation were showed between DPD and the months after menarche. These results were suggested that Bone Metabolism was partial matured on 18-19 years. Than it was so important to follow up 2-3 years.