Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo

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  • Nakazeki, Fumiko
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Nishiga, Masataka
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Horie, Takahiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Nishi, Hitoo
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Nakashima, Yasuhiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Baba, Osamu
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Kuwabara, Yasuhide
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Nishino, Tomohiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Nakao, Tetsushi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Ide, Yuya
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Koyama, Satoshi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Kimura, Masahiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Tsuji, Shuhei
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Sowa, Naoya
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Yoshida, Shigeo
    Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences
  • Conway, Simon J.
    Herman B Wells Center for Pediatric Research, Indiana University of Medicine
  • Yanagita, Motoko
    Department of Nephrology, Graduate School of Medicine, Kyoto University
  • Kimura, Takeshi
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
  • Ono, Koh
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University

Description

Recent evidence suggests that the accumulation of macrophages as a result of obesity-induced adipose tissue hypoxia is crucial for the regulation of tissue fibrosis, but the molecular mechanisms underlying adipose tissue fibrosis are still unknown. In this study, we revealed that periostin (Postn) is produced at extraordinary levels by adipose tissue after feeding with a high-fat diet (HFD). Postn was secreted at least from macrophages in visceral adipose tissue during the development of obesity, possibly due to hypoxia. Postn⁻/⁻ mice had lower levels of crown-like structure formation and fibrosis in adipose tissue and were protected from liver steatosis. These mice also showed amelioration in systemic insulin resistance compared with HFD-fed WT littermates. Mice deficient in Postn in their hematopoietic compartment also had lower levels of inflammation in adipose tissue, in parallel with a reduction in ectopic lipid accumulation compared with the controls. Our data indicated that the regulation of Postn in visceral fat could be beneficial for the maintenance of healthy adipose tissue in obesity.

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