A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica
Bibliographic Information
- Other Title
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- A femtomolar-range suicide germination stimulant for the parasitic plant <i>Striga hermonthica</i>
Description
The parasitic plant Striga hermonthica has been causing devastating damage to the crop production in Africa. Because Striga requires host-generated strigolactones to germinate, the identification of selective and potent strigolactone agonists could help control these noxious weeds. We developed a selective agonist, sphynolactone-7, a hybrid molecule originated from chemical screening, that contains two functional modules derived from a synthetic scaffold and a core component of strigolactones. Cooperative action of these modules in the activation of a high-affinity strigolactone receptor ShHTL7 allows sphynolactone-7 to provoke Striga germination with potency in the femtomolar range. We demonstrate that sphynolactone-7 is effective for reducing Striga parasitism without impinging on host strigolactone-related processes.
Journal
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- Science
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Science 362 (6420), 1301-1305, 2018-12-14
American Association for the Advancement of Science
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Details 詳細情報について
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- CRID
- 1050845763744086912
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- NII Article ID
- 120006623828
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- ISSN
- 10959203
- 00368075
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- HANDLE
- 2237/00030159
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN