反復温熱刺激のII型糖尿病患者血糖とHbA1cならびに血小板グルタチオン代謝に及ぼす影響

大塚, 吉則, 薮中, 宗之, 高山, 茂, 阿岸, 祐幸

To know the effect of repeated thermal stimulation on antioxidative defense system in patients with diabetes，gl utathione metabolism in the platelet was studied before and after one month balneotherapy in 12 non-insulin-dependent diabetic patients. The patients were instructed to take a bath twice or thrice a day at water temperature of 39℃～40℃. Before the balneotherapy，the levels of GSH in the platelet were well correlated with those of fasting plasma glucose (FPG，r=0.692，P <0.05)，which suggested that GSH synthesis was induced by diabetes (or oxidative stress). After the balneotherapy，in well-controlled patients (FPG< 150 mg/dl)，the lebel of GSH increased (P<O.O1)，and in poorly controlled patients (FPG≧150 mg/dl)，the level decreased (P< 0.05). These findings indicate that oxidative stress is decreased by balneotherapy. There was a negative correlation between glutathione peroxidase (GPX) activities and the levels of FPG (r= -0.430，P <0.05)，which implied that antioxidative defense system was damaged in diabetic patients. After balneotherapy，the GPX activity decreased in patients with severe diabetic complications，indicating that in these patients antioxidative defense system hardly recovered. The levels of lipid peroxide (LPO) also decreased in these patients. From these findings，we conclude that，the platelet glutathione metabolism can be partly improved by balneotherapy，and the favorable effect of balneotherapy seems to be dependent on the existence of diabetic complications and the plasma glucose level.

反復温熱刺激のII型糖尿病患者血糖とHbA1cならびに血小板グルタチオン代謝に及ぼす影響

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