Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study)
書誌事項
- タイトル別名
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- Scientific basis for the anti dementia drugs of constituents from Ashwagandha Withania somnifera
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説明
Although Ashwagandha (root of Withania somnifera) has been used for multi purposes but mainly as a tonic in the traditional Indian Ayurvedic medicine, this review focused on nootropic effects of Ashwagandha itself and isolated compounds from it. Several reports showed sitoindosides VII-X as active compounds for cognitive enhancer. However, our study revealed other active constituents, withanolide A, withanoside IV and withanoside VI, could improve Aβ(25-35) induced memory impairment, neuronal atrophy and synaptic loss in the cerebral cortex and the hippocampus. Treatment with Aβ(25-35) induced axonal and dendritic atrophy, and pre-synaptic and post-synaptic losses also in cultured rat cortical neurons. Subsequent treatment with withanolide A, withanoside IV and withanoside VI induced significant reconstruction of pre-synapses and post-synapses, in addition to regeneration of both axons and dendrites in the neurons. Withanolide A, withanoside IV and withanoside VI are therefore important candidates for the therapeutic treatment of neurodegenerative diseases, as it is able to reconstruct neuronal networks.
収録刊行物
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- 和漢医薬学雑誌 = Journal of traditional medicines
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和漢医薬学雑誌 = Journal of traditional medicines 22 (supll.), 176-182, 2005
和漢医薬学会
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詳細情報 詳細情報について
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- CRID
- 1050845764032726016
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- NII論文ID
- 110002555190
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- NII書誌ID
- AA12035198
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- ISSN
- 18801447
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- HANDLE
- 10110/2316
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- NDL書誌ID
- 7489091
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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