動脈硬化度の指標としての高感度CRPに影響を及ぼす脳卒中危険因子の検討

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  • ドウミャク コウカド ノ シヒョウ ト シテ ノ コウカンド CRP ニ エイキョウ オ オヨボス ノウソッチュウ キケン インシ ノ ケントウ
  • The Investigation of the Adverse effects to High C-reactive Protein by the Risk Factors to Cerebrovascular Strokes

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Abstract

Background: Cerebrovascular strokes often induce fatal or serious neurological deficits in the patients those suffer from these disorders. To say nothing, it is valuable to investigate not only the organic abnoromalities such as the unruptured aneurysm or arteriovenous malformations but also the degree of the arterioscrelosis quantiatively in the brain dock. Therefore, we tried to search for the appropriate quantitative method. Purpose: At this time, we have paid the caution to the high C-reactive protein (hCRP) which is considered to be intensively related to the arteriosclerosis as the method of it. The purpose of our research is to demonstrate the statistical significance between the data of hCRP and those of the items with arteriosclerosis. Clinical materials (patients) and methods: Clinical materials were patients those referred to our institute (Pasia Garden Clinic) to undergo brain dock (The total number is 469). Initially, we tried the statistical significance between the data of hCRP and those of 17 items concerning cerebrovascular strokes (CVS). Then, we tried to obtain the summation of the number of the presented risk factors of the CVS and analyze the statistical significance between the summation of the number and the data of hCRP in each patient similarly with the former other data. We used the Spearman's test as the statistical method. Statistical significance was established as p < 0.05. Results: Statistical significance was obtained in 8 items (body fat percentage, body mass index, girth of the abdomen, HDL-cholesterol, bilateral pulse velocity, triglyceride, uremic acid). On the other hand, it was not identified in 9 items (the number of CVS risk factors, age, the amounts of having alcohol, the score of A type character, Brinkman Index, fasting blood sugar, hemoglobin-A1c, Total and LDL cholesterol, hemoglobin A1c, Urine pH). Concerning the Odds ratio of the CVS items with the statistical significance was 0.78. The statistical significance between the total summation of CVS and the data of hCRP was not obtained against our expectation. Conclusion: To date, considering the Odds ratio described as above, hCRP is not necessarily almighty as the index to predict the CVS. Hereafter, we would like to increase the number of the clinical materials (patients) and try to demonstrate the significance as the index of CVS using another statistical methods.

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