ベロ毒素によるTNF -αの産生誘導とカスパーゼ-3の活性化および抗菌剤による抑制効果の検討

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  • TNF-a Induction and Caspase-3 Activation by Verotoxin and Effects of Antibiotics on the Apoptosis－Related Factors

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Verotoxin （VT） produced by enterohemorrhagic Escherichia coli （EHEC） is associated with hemolytic uremic syndrome （HUS）. VT induces apoptosis in several kinds of tissues and cell lines such as pediatric tubular cells which are considered to be one of the target tissues for HUS. TNF-α, which is induced by VT or EHEC lipopolysaccharide, stimulates the VT-induced apoptosis. ln this study, we have demonstrated that VT1 caused caspase-3 activation in THP-1 cells, and that azithromycin （AZM）significantly inhibited TNF-α induction by VT1 in peripheral blood mononuclear cells. These data provide a useful in vitro model to investigate the mechanism of VT-induced apoptosis through caspase-3, and the suggestion on a possible use of AZM as an immunomodulator to downregurate TNF－α induction

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