ヒト肺癌実験モデルの作製に関する研究　第1編　ヒト肺扁平上皮癌細胞株(EBC-1株)およびヒト肺腺癌細胞株(ABC-1株)の樹立とその性状

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  • Experimental model of human lung cancer Part I. Establishment and characterization of new tissue culture cell lines from human squamous cell carcinoma and adenocarcinoma of the lung.

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Two human lung cancer cell lines designated as EBC-1 and ABC-1 were newly established for the purpose of making an in vitro experimental model of human lung cancer. The EBC-1 line was established from a metastatic skin tumor of a patient with squamous cell carcinoma of the lung. The cells grew in a monolayered sheet with a population-doubling time of 42 hr. The chromosome number showed wide variation from 35 to 102 with a modal peak at 53. The ABC-1 line was established from pleural effusion of a patient with adenocarcinoma of the lung. The cells grew mainly in a floating clump with a population-doubling time of 72 hr. Karyotypic analysis disclosed a wide variation from 25 to 57 with two modal peaks at 53 and 54. The EBC-1 and ABC-1 lines may be useful for biological, cytopharmacological and therapeutic studies of human squamous cell carcinoma and adenocarcinoma of the lung.

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