Liver fat accumulation assessed by computed tomography is an independent risk factor for diabetes mellitus in a population-based study: SESSA (Shiga Epidemiological Study of Subclinical Atherosclerosis).
抄録
type:Journal Article
AIMS:Ectopic fat accumulation is related to insulin resistance and diabetes mellitus (DM). However, the effect of fatty liver on DM in non-obese individuals has not been clarified. We investigated whether liver fat accumulation assessed by computed tomography (CT) is associated with the incidence of DM.
METHODS:In a prospective population-based study, 640 Japanese men were followed up for 5 years. The liver to spleen (L/S) ratio of the CT attenuation value was used as the liver fat accumulation index. We calculated the odds ratio (OR) and 95% confidence interval (CI) for the DM incidence of per 1 standard deviation (SD) lower L/S and those of L/S < 1.0 compared with L/S ≥ 1.0, using logistic regression models.
RESULTS:Both per 1 SD lower L/S and L/S < 1.0 were significantly associated with a risk for DM incidence (1 SD lower L/S: OR = 1.57, 95%CI = 1.14-2.16; L/S < 1.0: OR = 2.27, 95%CI = 1.00-5.14). The relationship between L/S and incidence of DM was consistent in the obese and non-obese groups, with thresholds of BMI 25 kg/m2, waist circumference 85 cm, or visceral adipose tissue 100 cm2.
CONCLUSIONS:Liver fat accumulation assessed by CT was associated with the incidence of DM.
収録刊行物
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- Diabetes research and clinical practice
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Diabetes research and clinical practice 160 108002-, 2020-01-03
Elsevier Scientific Publishers
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詳細情報 詳細情報について
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- CRID
- 1050846638690556160
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- NII論文ID
- 120006791579
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- ISSN
- 18728227
- 01688227
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- Crossref
- CiNii Articles
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