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ZGLP1 is a determinant for the oogenic fate in mice
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Description
Mammalian sexual reproduction relies on the dichotomy of male and female germ cell development. However, the underlying mechanisms remain unclear. Here, we show that ZGLP1, a conserved transcriptional regulator with GATA-like zinc fingers, determines the oogenic fate in mice. ZGLP1 acts downstream of bone morphogenetic protein (BMP), but not retinoic acid (RA), and is essential for the oogenic program and meiotic entry. ZGLP1 overexpression induces differentiation of in vitro primordial germ cell-like cells (PGCLCs) into fetal oocytes by activating the oogenic programs repressed by Polycomb activities, whereas RA signaling contributes to the oogenic program maturation and PGC program repression. Our findings elucidate the mechanism for mammalian oogenic fate determination, providing a foundation for promoting in vitro gametogenesis and reproductive medicine.
Journal
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- Science
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Science 367 (6482), eaaw4115-, 2020-03-06
American Association for the Advancement of Science (AAAS)
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Keywords
- Male
- Mice, Knockout
- Sex Differentiation
- Gene Expression Regulation, Developmental
- Polycomb-Group Proteins
- Tretinoin
- Sex Determination Processes
- Repressor Proteins
- Meiosis
- Mice
- Fetus
- Oogenesis
- Bone Morphogenetic Proteins
- Oocytes
- Animals
- Female
- Transcriptome
- Adaptor Proteins, Signal Transducing
- Signal Transduction
- Transcription Factors
Details 詳細情報について
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- CRID
- 1050848249735156608
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- NII Article ID
- 120006850276
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- ISSN
- 00368075
- 10959203
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- HANDLE
- 2433/251201
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- PubMed
- 32054698
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE