Identification of Amnesic MCI Using AERP P300 Based on J-ADNI Differentiation Criteria : Insights into MCI from a Neuropsychology Viewpoint

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  • J-ADNI鑑別基準における聴性事象関連電位P300によるMCIの同定 : 神経心理学的視点からMCIを捉える (特集 認知症)
  • J-ADNI鑑別基準における聴性事象関連電位P300によるMCIの同定 : 神経心理学的視点からMCIを捉える
  • J-ADNI カンベツ キジュン ニ オケル チョウセイ ジショウ カンレン デンイ P300 ニ ヨル MCI ノ ドウテイ : シンケイ シンリガクテキ シテン カラ MCI オ トラエル

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A report from Ministry of Health, Labour and Welfare estimates that approximately 4 million has Mild Cognitive Impairment (MCI), where the prevalence among the elderly is approximately 13%. Important strategy against dementia involves early detection of and early intervention for MCI, which is seen as a preceding stage before dementia. MCI is a stage where some level of daily activity is maintained while forgetfulness progresses, cognitive ability lies within normal range although some kind of functional decline manifests. The amnesia-type MCI, where the chief complaint is memory loss, currently receives highest attention. In this paper, we have decided to focus on J-ADNI differentiation from Japan. We measured information processing rate using auditory event-related potential to study its relationship with logical memory. As a result, significant differences were detected for event-related potential components between the MCI and control groups with 0.001 as significance level. Thus, it was suggested that the evaluation of logical memory can be effective for detection of MCI, and that the delay of auditory information processing can lead to deterioration of verbal memory. These results support the idea that memory in neuropsychological pyramid (Rusk, NY Univ.) resides at higher order than the information processing stage. Differentiation in this study is strictly for the amnesia type. In addition to the strategy toward dementia prevention through various occupational therapist activities, speech therapist training is essential for addressing verbal amnesia. Further studies in the rehabilitation field are needed to promote dementia prevention

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