A synthetic ion channel with anisotropic ligand response
説明
Biological membranes play pivotal roles in the cellular activities. Transmembrane proteins are the central molecules that conduct membrane-mediated biochemical functions such as signal transduction and substance transportation. Not only the molecular functions but also the supramolecular properties of the transmembrane proteins such as self-assembly, delocalization, orientation and signal response are essential for controlling cellular activities. Here we report anisotropic ligand responses of a synthetic multipass transmembrane ion channel. An unsymmetrical molecular structure allows for oriented insertion of the synthetic amphiphile to a bilayer by addition to a pre-formed membrane. Complexation with a ligand prompts ion transportation by forming a supramolecular channel, and removal of the ligand deactivates the transportation function. Biomimetic regulation of the synthetic channel by agonistic and antagonistic ligands is also demonstrated not only in an artificial membrane but also in a biological membrane of a living cell.
収録刊行物
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- Nature Communications
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Nature Communications 11 2494-, 2020-06-10
Springer Nature
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詳細情報 詳細情報について
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- CRID
- 1050848249893668480
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- NII論文ID
- 120006878529
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- ISSN
- 20411723
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- HANDLE
- 2433/254046
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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