High serum concentrations of autoantibodies to HSP47 in nonspecific interstitial pneumonia compared with idiopathic pulmonary fibrosis
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説明
Background: The pathological diagnosis of idiopathic interstitial pneumonias (IIP) by surgical lung biopsy is important for clinical decision-making. However, there is a need to use less invasive biomarkers to differentiate nonspecific interstitial pneumonia (NSIP) from other IIP such as usual interstitial pneumonia (UIP). Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. HSP47 is increased in various fibrotic diseases. We investigated the autoantibodies to HSP47 in IIPs. Methods: We measured the serum levels of the autoantibodies to HSP47 in 38 patients with various forms of IIP [16 with idiopathic pulmonary fibrosis (IPF), 15 with idiopathic NSIP, 7 with cryptogenic organizing pneumonia (COP)] and 18 healthy volunteers. Results: The serum levels of autoantibodies to HSP47 in patients with idiopathic NSIP were significantly higher than in patients with IPF (P < 0.01), COP (P < 0.05), and healthy volunteers (P < 0.05). In addition, those in fibrosing NSIP were significantly higher than those of cellular and fibrosing NSIP (p < 0.05). Conclusion: We found high levels of anti-HSP47 autoantibody titers in sera of patients with idiopathic fibrosing NSIP compared with other IIPs and healthy volunteers.
収録刊行物
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- BMC Pulmonary Medicine
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BMC Pulmonary Medicine 8 23-, 2008-11-04
BioMed Central
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キーワード
- Pulmonary and Respiratory Medicine
- Adult
- Male
- RC705-779
- 610
- Enzyme-Linked Immunosorbent Assay
- Middle Aged
- Idiopathic Pulmonary Fibrosis
- Diagnosis, Differential
- Diseases of the respiratory system
- Humans
- Female
- Lung Diseases, Interstitial
- HSP47 Heat-Shock Proteins
- Biomarkers
- Research Article
- Aged
- Autoantibodies
- Follow-Up Studies
- Retrospective Studies
詳細情報 詳細情報について
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- CRID
- 1050850247216026624
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- NII論文ID
- 120006981741
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- NII書誌ID
- AA12035438
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- ISSN
- 14712466
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- HANDLE
- 10069/20835
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- PubMed
- 18983650
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- Web Site
- https://nagasaki-u.repo.nii.ac.jp/records/19010
- http://link.springer.com/content/pdf/10.1186/1471-2466-8-23.pdf
- http://link.springer.com/article/10.1186/1471-2466-8-23/fulltext.html
- http://link.springer.com/content/pdf/10.1186/1471-2466-8-23
- https://link.springer.com/content/pdf/10.1186/1471-2466-8-23.pdf
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- CiNii Articles
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