A Synthesis of Lamellarins via Regioselective Assembly of 1,2,3-Differentially Substituted 5,6-Dihydropyrrolo[2,1-a]Isoquinoline Core
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抄録
A modular synthesis of the marine natural products lamellarins has been developed. The key reactions utilized are C3-selective Vilsmeier-Haack formylation followed by iterative bromination/cross-coupling of the 5,6-dihydropyrrolo[2,1-a]isoquinoline core. The 1,2-diaryl-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carbaldehyde thus synthesized was readily converted to the lamellarin skeleton by mean of palladium-catalyzed oxidative lactonization.
HETEROCYCLES, 91(4), pp.782-794; 2015
収録刊行物
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- HETEROCYCLES
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HETEROCYCLES 91 (4), 782-794, 2015
日本複素環化学研究所
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詳細情報 詳細情報について
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- CRID
- 1050850247217181056
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- NII論文ID
- 120006987123
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- NII書誌ID
- AA00663739
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- ISSN
- 03855414
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- HANDLE
- 10069/35307
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- NDL書誌ID
- 026309668
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- NDL
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