Divergent Total Synthesis of Azalamellarins D and N

DOI IR HANDLE 47 References Open Access

Abstract

Lamellarins are polycyclic marine alkaloids with potent cytotoxic activities against cancer cell lines. A divergent synthesis of azalamellarins D and N, lactam congeners of the marine natural products lamellarins D and N, has been achieved via the pentacyclic 14-bromo-8,9-dihydro-benzo[7,8]indolizino[3,2-c]- quinolin-6(5H)-one intermediate. The pentacyclic intermediate can be synthesized from methyl 1-(benzensulfonyl)-3-bromo-1H-pyrrole-2-carboxylate via the Suzuki–Miyaura cross-coupling and intramolecular direct arylation as key reactions.

Heterocycles, 103 (2), pp862-877; 2021

Journal

  • HETEROCYCLES

    HETEROCYCLES 103 (2), 862-877, 2021-02-08

    日本複素環化学研究所

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