Adreneic acid as an inflammation enhancer in non-alcoholic fatty liver disease
書誌事項
- タイトル別名
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- Adrenic acid as an inflammation enhancer in non-alcoholic fatty liver disease
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説明
Background: This study was designed to identify novel links between lipid species and disease progression in non-alcoholic fatty liver disease (NAFLD). Methods: We analyzed lipid species in the liver and plasma of db/db mice fed a choline-deficient l-amino acid-defined, high-fat diet (CDAHFD) using liquid chromatography/mass spectrometry (LC/MS). An in vitro experiment was performed using HepG2 cells stimulated with recombinant human TNFα or IL1β. The expression of steatosis-, inflammation-, and fibrosis-related genes were analyzed. Plasma samples from NAFLD patients were also analyzed by LC/MS. Results: The CDAHFD-fed db/db mice with hepatic steatosis, inflammation, mild fibrosis, obesity, and hypercholesterolemia displayed significantly higher hepatic and plasma levels of free adrenic acid (p < 0.05). The accumulated adrenic acid in the CDAHFD-fed db/db mice was associated with increased expression of ELOVL2 and 5, and the suppression of the acyl-CoA oxidase 1 gene during peroxisomal β-oxidation. The pretreatment of HepG2 cells with adrenic acid enhanced their cytokine-induced cytokines and chemokines mRNA expression. In NAFLD patients, the group with the highest ALT levels exhibited higher plasma adrenic acid concentrations than the other ALT groups (p-value for trend <0.001). Conclusion: Data obtained demonstrated that adrenic acid accumulation contributes to disease progression in NAFLD.
収録刊行物
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- Archives of Biochemistry and Biophysics
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Archives of Biochemistry and Biophysics 623–624 64-75, 2017-06
Elsevier
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詳細情報 詳細情報について
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- CRID
- 1050856995323029248
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- NII論文ID
- 120006653251
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- NII書誌ID
- AA00547159
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- ISSN
- 10960384
- 00039861
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- HANDLE
- 20.500.14094/90006178
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- PubMed
- 28456640
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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