Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity
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- 辻花, 光次郎
- Graduate School of Pharmaceutical Sciences, Kyoto University; Department of Dermatology, Graduate School of Medicine, Kyoto University
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- 種子島, 幸祐
- Stem Cell Project, Tokyo Metropolitan Institute of Medical Science
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- 三戸, 靖子
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 山田, 裕之
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 赤澤, 壮太
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 中尾, 龍太
- Department of Pathology and Cell Regulation, Kyoto Prefectural University of Medicine
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- 冨永, 恵子
- Graduate School of Frontier Biosciences, Osaka University
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- 斎藤, 理佐
- Stem Cell Project, Tokyo Metropolitan Institute of Medical Science; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
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- 西藤, 泰昌
- Core Technology and Research Center, Tokyo Metropolitan Institute of Medical Science
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- 畑, 隆一郎
- Oral Health Science Research Center, Graduate School of Kanagawa Dental University
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- 中村, 友紀
- Institute for the Advanced Study of Human Biology, Kyoto University Institute for Advanced Study, Kyoto University; The Hakubi Center for Advanced Research, Kyoto University; Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University
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- 村井, 伊織
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 河野, 有香
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 須川, 真帆
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 谷岡, 未樹
- Department of Dermatology, Graduate School of Medicine, Kyoto University
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- 江川, 形平
- Department of Dermatology, Graduate School of Medicine, Kyoto University
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- 土居, 雅夫
- Graduate School of Pharmaceutical Sciences, Kyoto University
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- 伊佐, 正
- Department of Neuroscience, Graduate School of Medicine, Kyoto University
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- 椛島, 健治
- Department of Dermatology, Graduate School of Medicine, Kyoto University
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- 原, 孝彦
- Stem Cell Project, Tokyo Metropolitan Institute of Medical Science; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University; Graduate School of Science, Department of Biological Science, Tokyo Metropolitan University
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- 岡村, 均
- Graduate School of Pharmaceutical Sciences, Kyoto University; Department of Neuroscience, Graduate School of Medicine, Kyoto University
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説明
The epidermis is the outermost layer of the skin and the body’s primary barrier to external pathogens; however, the early epidermal immune response remains to be mechanistically understood. We show that the chemokine CXCL14, produced by epidermal keratinocytes, exhibits robust circadian fluctuations and initiates innate immunity. Clearance of the skin pathogen Staphylococcus aureus in nocturnal mice was associated with CXCL14 expression, which was high during subjective daytime and low at night. In contrast, in marmosets, a diurnal primate, circadian CXCL14 expression was reversed. Rhythmically expressed CXCL14 binds to S. aureus DNA and induces inflammatory cytokine production by activating Toll-like receptor (TLR)9-dependent innate pathways in dendritic cells and macrophages underneath the epidermis. CXCL14 also promoted phagocytosis by macrophages in a TLR9-independent manner. These data indicate that circadian production of the epidermal chemokine CXCL14 rhythmically suppresses skin bacterial proliferation in mammals by activating the innate immune system.
収録刊行物
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- Proceedings of the National Academy of Sciences (PNAS)
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Proceedings of the National Academy of Sciences (PNAS) 119 (25), 2022-06-21
National Academy of Sciences
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詳細情報 詳細情報について
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- CRID
- 1050857512396886656
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- ISSN
- 10916490
- 00278424
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- HANDLE
- 2433/277870
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- PubMed
- 35704759
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- KAKEN
- OpenAIRE
