Vibratory sound induces neurite outgrowth in PC12m3 cells in which nerve growth factor-induced neurite outgrowth is impaired

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  • 神経成長因子存在下で神経突起形成が見られないPC12m3細胞における低周波振動音刺激による神経突起の誘導
  • シンケイ セイチョウ インシ ソンザイカ デ シンケイ トッキ ケイセイ ガ ミラレナイ PC12m3 サイボウ ニ オケル テイシュウハ シンドウオン シゲキ ニ ヨル シンケイ トッキ ノ ユウドウ

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Abstract

A drug-hypersensitive PC12 mutant cell line (PC12m3) was obtained during continuous culturing of neural PC12 cells. In this study, PC12m3 cells were exposed to vibratory sound stimuli of frequencies ranging from 10 to 20,000Hz for 30 minutes at intensity 5, alone with the addition of NGF. The results showed that vibratory sounds of 20-150Hz induced enhancement of neurite outgrowth, whereas vibratory sound 10Hz and 150Hz to 20,000Hz had little effect on neurite outgrowth. The frequency of neurite outgrowth induced by 40-Hz sound stimuli was approximately 3-fold greater than that induced by NGF alone. Furthermore, our results showed that both vibratory sounds and sound waves, 40Hz and 200Hz, respectively, were the most effective. The reason for the discrepancy in frequency is not clear. However, the effect of 40-Hz vibratory sounds is consistent with the effect of the Vibratory Acoustic Therapy which mainly uses vibratory sounds between 40-Hz and 80-Hz.

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