Integrated genetic and clinical prognostic factors for aggressive adult T-cell leukemia/lymphoma
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- 亀田, 拓郎
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
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- 片岡, 圭亮
- Division of Hematology, Department of Medicine, Keio University School of Medicine; Division of Molecular Oncology, National Cancer Center Research Institute
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- 上運天, 綾子
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
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- 日高, 道弘
- National Hospital Organization Kumamoto Medical Center
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- 三好, 寛明
- Department of Pathology, Kurume University School of Medicine
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- 中野, 伸亮
- Department of Hematology, Imamura General Hospital
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- 野坂, 生郷
- Department of Hematology, Rheumatology and Infectious Diseases, Faculty of Life Sciences, Kumamoto University of Medicine
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- 吉満 誠
- Department of Hematology and Rheumatology, Kagoshima University Hospital
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- 安永, 純一朗
- Department of Hematology, Rheumatology and Infectious Diseases, Faculty of Life Sciences, Kumamoto University of Medicine; Institute for Frontier Life and Medical Sciences, Kyoto University
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- 木暮, 泰寛
- Division of Molecular Oncology, National Cancer Center Research Institute
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- 幣, 光太郎
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
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- 宮原, 正晴
- Department of Internal Medicine, Karatsu Red Cross Hospital
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- 阪本, 貴士
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 秋月, 渓一
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
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- 日髙, 智徳
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
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- 久冨木, 庸子
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
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- 古屋, 淳史
- Division of Molecular Oncology, National Cancer Center Research Institute
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- 河野, 徳明
- Department of Internal medicine, Miyazaki Prefectural Miyazaki Hospital
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- 山下, 清
- Department of Internal medicine, Miyazaki Prefectural Miyazaki Hospital
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- 河野, 浩
- Department of Internal medicine, Koga General Hospital
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- 外山, 孝典
- Department of Internal medicine, Miyazaki Prefectural Nobeoka Hospital
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- 前田, 宏一
- National Hospital Organization Miyakonojo Medical center
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- 丸塚, 浩助
- Department of Anatomic Pathology, Miyazaki Prefectural Miyazaki Hospital
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- 今泉, 芳孝
- Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
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- 加藤, 光次
- Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
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- 杉尾, 健志
- Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
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- 徳永, 雅仁
- Department of Hematology, Imamura General Hospital
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- 田代, 幸恵
- Department of Pathology, Imamura General Hospital
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- 髙折, 晃史
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
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- 宮﨑, 泰司
- Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University
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- 赤司, 浩一
- Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences
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- 石塚, 賢治
- Department of Hematology and Rheumatology, Kagoshima University Hospital
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- 松岡, 雅雄
- Department of Hematology, Rheumatology and Infectious Diseases, Faculty of Life Sciences, Kumamoto University of Medicine
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- 大島, 孝一
- Department of Pathology, Kurume University School of Medicine
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- 渡邊, 俊樹
- Department of Practical Management of Medical Information, St Marianna University, Graduate School of Medicine
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- 北中, 明
- Department of Laboratory Medicine, Kawasaki Medical School
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- 宇都宮, 與
- Department of Hematology, Imamura General Hospital
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- 小川, 誠司
- Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University
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- 下田, 和哉
- Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki
この論文をさがす
説明
The prognosis of aggressive adult T-cell leukemia/lymphoma (ATL) is poor, and allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is a curative treatment. To identify favorable prognostic patients after intensive chemotherapy, and who therefore might not require upfront allo-HSCT, we aimed to improve risk stratification of aggressive ATL patients aged <70 years. The clinical risk factors and genetic mutations were incorporated into risk modeling for overall survival (OS). We generated the m7-ATLPI, a clinicogenetic risk model for OS, that included the ATL prognostic index (PI) (ATL-PI) risk category, and non-silent mutations in seven genes, namely TP53, IRF4, RHOA, PRKCB, CARD11, CCR7, and GATA3. In the training cohort of 99 patients, the m7-ATLPI identified a low-, intermediate-, and high-risk group with 2-year OS of 100%, 43%, and 19%, respectively (hazard ratio [HR] 5.46, p < 0.0001). The m7-ATLPI achieved superior risk stratification compared to the current ATL-PI (C-index 0.92 vs. 0.85, respectively). In the validation cohort of 84 patients, the m7-ATLPI defined low-, intermediate-, and high-risk groups with a 2-year OS of 81%, 30%, and 0%, respectively (HR 2.33, p = 0.0094), and the model again outperformed the ATL-PI (C-index 0.72 vs. 0.70, respectively). The simplified m7-ATLPI, which is easier to use in clinical practice, achieved superior risk stratification compared to the ATL-PI, as did the original m7-ATLPI; the simplified version was calculated by summing the following: high-risk ATL-PI category (+10), low-risk ATL-PI category (−4), and non-silent mutations in TP53 (+4), IRF4 (+3), RHOA (+1), PRKCB (+1), CARD11 (+0.5), CCR7 (−2), and GATA3 (−3).
収録刊行物
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- Haematologica
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Haematologica 108 (8), 2178-2191, 2023-08
Ferrata Storti Foundation (Haematologica)
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詳細情報 詳細情報について
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- CRID
- 1050859989804918656
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- ISSN
- 15928721
- 03906078
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- HANDLE
- 2433/284568
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- PubMed
- 36794502
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- KAKEN
- OpenAIRE